A friend had a problem with tinySA Windows software, the one you can download here http://athome.kaashoek.com/tinySA/Windows/ . Everything looked fine, the COM port was recognised, just the software would not load. He got an error that a resource was not reachable, usable, accessible.
When I visited him I noticed that the Panda Antivirus from Panda Dome suite kept deleting the .exe every time I ran it. Even if the tinySA program was run as Administrator. While I am against whitelisting programs in antivirus software, it was the only way to get it running.
So if you are stuck in a similar situation with that software, find the way to convince your antivirus that it is bening.